Domain

Lipid transport, open beta-sheet (IPR009454)

Short name: Lipid_transpt_open_b-sht

Domain relationships

None.

Description

This entry represents a conserved open beta-sheet domain found in several lipid transport proteins, including vitellogenin and apolipoprotein B-100 [PMID: 9687371].

Vitellinogen precursors provide the major egg yolk proteins that are a source of nutrients during early development of oviparous vertebrates and invertebrates. Vitellinogen precursors are multi-domain apolipoproteins that are cleaved into distinct yolk proteins. Different vitellinogen precursors exist, which are composed of variable combinations of yolk protein components; however, the cleavage sites are conserved. In vertebrates, a complete vitellinogen is composed of an N-terminal signal peptide for export, followed by four regions that can be cleaved into yolk proteins: heavy chain lipovitellin (lipovitellin-1), phosvitin, light chain lipovitellin (lipovitellin-2), and a von Willebrand factor type D domain (YGP40) [PMID: 17314313, PMID: 12135361]. In vitellinogen, this domain is often found as part of the lipovitellin-1 peptide product.

Apolipoprotein B can exist in two forms: B-100 and B-48. Apoliporotein B-100 is present on several lipoproteins, including very low-density lipoproteins (VLDL), intermediate density lipoproteins (IDL) and low density lipoproteins (LDL), and can assemble VLDL particles in the liver [PMID: 16238675]. Apolipoprotein B-100 has been linked to the development of atherosclerosis.

GO terms

Biological Process

GO:0006869 lipid transport

Molecular Function

GO:0005319 lipid transporter activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam