UDP-glucose:Glycoprotein Glucosyltransferase (IPR009448)

Short name: UDP-g_GGtrans

Overlapping homologous superfamilies


Family relationships


The N-terminal region of this group of proteins is required for correct folding of the ER UDP-Glc: glucosyltransferase. These proteins selectively reglucosylates unfolded glycoproteins, thus providing quality control for protein transport out of the ER. Unfolded, denatured glycoproteins are substantially better substrates for glucosylation by this enzyme than are the corresponding native proteins. This protein and transient glucosylation may be involved in monitoring and/or assisting the folding and assembly of newly made glycoproteins, in order to identify glycoproteins that need assistance in folding from chaperones

GO terms

Biological Process

GO:0006486 protein glycosylation

Molecular Function

GO:0003980 UDP-glucose:glycoprotein glucosyltransferase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.