Family

Phosphatidylinositol anchor biosynthesis protein PIGW/GWT1 (IPR009447)

Short name: PIGW/GWT1

Overlapping homologous superfamilies

None.

Family relationships

None.

Description

Glycosylphosphatidylinositol (GPI) is a conserved post-translational modification to anchor cell surface proteins to plasma membrane in eukaryotes. PIGW and the yeast homologue GWT1 are involved in the addition of the acyl-chain to inositol in an early step of GPI biosynthesis [PMID: 12714589]. Mutations in PIGW are associated with West syndrome and hyperphosphatasia with mental retardation syndrome [PMID: 24367057].

GO terms

Biological Process

GO:0006506 GPI anchor biosynthetic process

Molecular Function

GO:0016746 transferase activity, transferring acyl groups

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PIRSF
Pfam
PANTHER