Domain

Beta-catenin-interacting ICAT (IPR009428)

Short name: ICAT

Domain relationships

None.

Description

This domain is characteristic of eukaryotic beta-catenin-interacting (ICAT) proteins. Beta-catenin is a multifunctional protein involved in both cell adhesion and transcriptional activation. Transcription mediated by the beta-catenin/Tcf complex is involved in embryological development and is upregulated in various cancers. ICAT selectively inhibits beta-catenin/Tcf binding in vivo, without disrupting beta-catenin/cadherin interactions [PMID: 12408824].

Protein LZIC contains a leucine zipper domain and an ICAT homologous domain, with particular conservation of residues that are used by ICAT for beta-catenin-binding [PMID: 11712074, PMID: 15932753].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0008013 beta-catenin binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam