Pre-mRNA-splicing factor Isy1 (IPR009360)

Short name: Isy1

Overlapping homologous superfamilies

Family relationships



This entry includes yeast Isy1 and it's homologues from plants and animals. In budding yeast, Isy1 is part of the NineTeen Complex (NTC), which is involved in spliceosome activation by specifying the interaction of U5 and U6 with pre-mRNA for their stable association with the spliceosome after U4 dissociation [PMID: 16540691]. The S. pombe homologue is known as Cwf12.

GO terms

Biological Process

GO:0000350 generation of catalytic spliceosome for second transesterification step

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.