Family

GRIM-19 (IPR009346)

Short name: GRIM-19

Family relationships

None.

Description

This family consists of several eukaryotic gene associated with retinoic-interferon-induced mortality 19 (GRIM-19) proteins. GRIM-19, was reported to encode a small protein primarily distributed in the nucleus and was able to promote cell death induced by IFN-beta and RA. A bovine homologue of GRIM-19 was co-purified with mitochondrial NADH:ubiquinone oxidoreductase (complex I) in bovine heart. Therefore, its exact cellular localisation and function are unclear. It has now been discovered that GRIM-19 is a specific interacting protein which negatively regulates Stat3 activity [PMID: 12628925].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
PANTHER