BMP and activin membrane-bound inhibitor (IPR009345)

Short name: BAMBI

Overlapping homologous superfamilies


Family relationships



This family consists of several eukaryotic BMP and activin membrane-bound inhibitor (BAMBI) proteins. Members of the transforming growth factor-beta (TGF-beta) superfamily, including TGF-beta, bone morphogenetic proteins (BMPs), activins and nodals, are vital for regulating growth and differentiation. BAMBI is related to TGF-beta-family type I receptors but lacks an intracellular kinase domain.

BAMBI is an essential regulator of cell proliferation and differentiation that represses transforming growth factor-beta and enhances Wnt/beta-catenin signalling in various cell types [PMID: 26247931]. It stably associates with TGF-beta-family receptors and inhibits BMP and activin as well as TGF-beta signalling [PMID: 10519551].

GO terms

Biological Process

GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0090263 positive regulation of canonical Wnt signaling pathway

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.