Ethanolamine utilisation EutS (IPR009307)

Short name: EutS

Overlapping homologous superfamilies

Family relationships



This family consists of bacterial EutS ethanolamine utilisation proteins and PduU propanediol utilization proteins.

Bacterial microcompartments (BCMs) function as organelles by sequestering particular metabolic processes within the cell. The shells of varied microcompartments are built primarily from small proteins belonging to the bacterial microcompartment (BMC) domain family. PduU exists as a hexamer which might further assemble into the flat facets of the polyhedral outer shell of the pdu microcompartments [PMID: 18786396]. This proteinaceous noncarboxysome microcompartment is involved in coenzyme B12-dependent degradation of 1,2-propanediol [PMID: 12923081]. The core of PduU is related to the typical bacterial BMC domain and its natural oligomeric state is a cyclic hexamer. Unlike other typical BMC domain proteins, the 3D topology of PduU reveals a circular permuted variation on the typical BMC fold which leads to several unique features. The exact functions related to those unique features are still not clear. Another difference is the presence of a deep cavity on one side of the hexamer as well as an intermolecular six-stranded beta barrel that seems to block the central pore that is present in other BMC domain proteins.

EutS proteins included in this family are sequence homologues of PduU. They are encoded within eut operon and may be required for the formation of the outer shell of bacterial eut polyhedral organelles which are involved in the cobalamin-dependent degradation of ethanolamine [PMID: 10464203, PMID: 20044574].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0031469 polyhedral organelle

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.