Transcription initiation Spt4 (IPR009287)

Short name: Spt4

Overlapping homologous superfamilies

Family relationships



This family consists of several eukaryotic transcription initiation Spt4 proteins. Three transcription-elongation factors Spt4, Spt5, and Spt6 are conserved among eukaryotes and are essential for transcription via the modulation of chromatin structure. Spt4 and Spt5 are tightly associated in a complex, while the physical association of the Spt4-Spt5 complex with Spt6 is considerably weaker. It has been demonstrated that Spt4, Spt5, and Spt6 play roles in transcription elongation in both yeast and humans including a role in activation by Tat. It is known that Spt4, Spt5, and Spt6 are general transcription-elongation factors, controlling transcription both positively and negatively in important regulatory and developmental roles [PMID: 11182892].

GO terms

Biological Process

GO:0032786 positive regulation of DNA-templated transcription, elongation
GO:0006355 regulation of transcription, DNA-templated

Molecular Function

GO:0008270 zinc ion binding

Cellular Component

GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.