Transmembrane protein 176A/B (IPR009281)

Short name: TMEM176A/TMEM176B

Overlapping homologous superfamilies


Family relationships


Transmembrane (TMEM)-176A and 176B proteins are closely related to MS4A (membrane-spanning 4-domains subfamily A) proteins [PMID: 20186339]. Their levels are significantly elevated in certain cancers [PMID: 22244448, PMID: 12097419]. TMEM176B (LR8, Torid, Clast1) is broadly expressed, but was up regulated in antigen presenting cells in a rat model of allograft tolerance [PMID: 16095493]. Their role in the immune system is unclear.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.