Repeat

Coagulation factor V, LSPD (IPR009271)

Short name: Coagulation_factor_V_LSPD

Description

The name LSPD derives from the conserved residues in the middle of the repeat. These repeats are found in coagulation factor V and occur in the B domain, which is cleaved prior to activation of the protein. It has been suggested that domain B bring domains A and C together for activation [PMID: 11229814].

Coagulation factor V is a central regulator of hemostasis and serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin.

GO terms

Biological Process

GO:0007596 blood coagulation

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam