Domain

Laminin I (IPR009254)

Short name: Laminin_I

Domain relationships

None.

Description

Laminins are glycoproteins that are major constituents of the basement membrane of cells. Laminins are trimeric molecules; laminin-1 is an alpha1 beta1 gamma1 trimer. It has been suggested that the domains I and II from laminin A, B1 and B2 may come together to form a triple helical coiled-coil structure [PMID: 3182802]. Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organisation of cells into tissues during embryonic development by interacting with other extracellular matrix components.

GO terms

Biological Process

GO:0030155 regulation of cell adhesion
GO:0030334 regulation of cell migration
GO:0045995 regulation of embryonic development

Molecular Function

GO:0005102 receptor binding

Cellular Component

GO:0005606 laminin-1 complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam