Repeat

Adenomatous polyposis coli protein, 15 residue repeat (IPR009240)

Short name: APC_15aa_rpt

Description

The 15 aa repeat is found in the APC protein family. It is involved in binding beta-catenin [PMID: 9823329] along with the IPR009223 repeats. Many human cancer mutations map to the region around these motifs, and may be involved in disrupting their binding of beta-catenin.

GO terms

Biological Process

GO:0016055 Wnt signaling pathway

Molecular Function

GO:0008013 beta-catenin binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam