Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein (IPR009220)

Short name: tRNA_threonyl_synthase/kinase

Overlapping homologous superfamilies


Family relationships



This entry describes a probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein. Its N-termanal domain is homologous to the Kae1/YgjD family, which is involved in tRNA threonylcarbamoyladenosine biosynthesis [PMID: 21285948]. Its C-terminal region contains a serine/threonine protein kinase domain (STYKS) and is homologous to Bud32. Kae1 and Bud32 are two components of the the KEOPS/EKC complex, which has been implicated in transcription, telomere maintenance and chromosome segregation [PMID: 21183954]. In this archaeal family, it seems that the Kae1 and Bud32 orthologues are fused.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0004222 metalloendopeptidase activity
GO:0008270 zinc ion binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.