Family

Methylthioribose kinase (IPR009212)

Short name: Methylthioribose_kinase

Family relationships

None.

Description

Members of this family are 5-methylthioribose kinases (EC:2.7.1.100) that catalyse phosphorylation of 5-methylthioribose (MTR), a step in the recycling of methionine from 5'-methylthioadenosine, a co-product of polyamine biosynthesis. The preceding step of methylthioadenosine (MTA) hydrolysis to MTR is catalysed by 5'-methylthioadenosine/S-adenosylhomocysteine (MTA/AdoHcy) nucleosidase.

Bacillus subtilis protein MtnK (formerly YkrT) [PMID: 11545674] and Klebsiella pneumoniae protein MtrK [PMID: 8694776] have been experimentally characterised. K. pneumoniae MtrK expression is regulated by methionine [PMID: 8393067].

As this enzyme is absent in mammals, it has been considered a target for rational drug design.

GO terms

Biological Process

GO:0009086 methionine biosynthetic process

Molecular Function

GO:0046522 S-methyl-5-thioribose kinase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
HAMAP
PIRSF
TIGRFAMs