Family

Predicted retinoblastoma binding protein (RIZ) (IPR009170)

Short name: RIZ_retinblastoma-bd_prot

Family relationships

None.

Description

Retinoblastoma protein is a tumour suppressor thought to be involved in the transcriptional control of the cell cycle and differentiation. This entry represents RIZ, a zinc-finger protein which has been shown to interact with the retinoblastoma protein, and which is highly expressed in retinoblastoma cell lines and brain tumours [PMID: 8654390, PMID: 9006946, PMID: 7538672]. Expression has also been demonstrated in a variety of normal cell lines, suggesting a role in cell growth or differentiation. Binding of RIZ to the macrophage-specific TPA-responsive element of the haem oxygenase 1 gene suggests that one its functions is as a transcriptional activator of this gene.

GO terms

Biological Process

GO:0006355 regulation of transcription, DNA-templated

Molecular Function

GO:0003677 DNA binding
GO:0046872 metal ion binding

Cellular Component

GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PIRSF