Erythropoietin receptor (IPR009167)

Short name: Erythropoietin_rcpt

Overlapping homologous superfamilies


Family relationships



A number of receptors for lymphokines, hematopoietic growth factors and growth hormone-related molecules have been found to share a common binding domain. These receptors are designated as hematopoietin receptors [PMID: 1400369] and the corresponding ligands as hematopoietins. Further, hematopoietins have been subdivided into two major structural groups: Large/long and small/short hematopoietins.

Several receptor chains for large hematopoietins are structurally related such that their extracellular parts strictly contain the 200 amino-acids hematopoietin domain, duplicated in the thrombopoietin receptor and in avian prolactin receptors. This subgroup of receptor chains contains: Growth hormone receptor (GHR), Prolactin receptor (PRLR), Erythropoietin receptor (EPOR), Thrombopoietin receptor (TPOR).

A schematic representation of the structure of these receptors is shown below:

 | C C       C  C  Extracellular          XXXXXXX       Cytoplasmic       |
   | |       |  |                      Transmembrane
   +-+       +--+

These receptor chains are single components of receptors that homodimerise upon binding of the cognate cytokine, following the structural model described for the growth hormone-receptor complex [PMID: 1549776].

This entry describes receptors for erythropoietin (EPO), a plasma glycoprotein, which is the primary physiological mediator of erythrocite production [PMID: 3773894]. They are expressed in relatively mature erythroid progenitor cells and in EPO-responsive erythroleukemia cells, and their physiological role is to mediate erythropoietin- induced erythroblast proliferation and differentiation. The receptors dimerise upon stimulation, triggering the JAK2/STAT5 signalling cascade [PMID: 8068943, PMID: 8657137].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0004888 transmembrane signaling receptor activity

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.