6-phosphofructokinase, eukaryotic type (IPR009161)

Short name: 6-phosphofructokinase_euk

Family relationships



Members of this family are eukaryotic (with one exception) ATP-dependent 6-phosphofructokinases (EC: in which two tandem copies of the phosphofructokinase are found [PMID: 10091602]. Members are found, often including several isozymes, in animals and fungi and in the bacterium Propionibacterium acnes KPA171202 (a human skin commensal).

Phosphofructokinase (PFK) catalyses the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate, which then enters the Embden-Meyerhof pathway. PFK is a key regulatory enzyme in glycolysis.

GO terms

Biological Process

GO:0006096 glycolytic process

Molecular Function

GO:0003872 6-phosphofructokinase activity
GO:0005524 ATP binding

Cellular Component

GO:0005737 cytoplasm

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.