Family

Basigin (IPR009151)

Short name: Basigin

Family relationships

None.

Description

The basigins are members of the immunoglobulin superfamily. They are present on the surface of tumour cells and stimulate nearby fibroblasts to synthesise matrix metalloproteases (MMPs), which play an important role in tumour invasiveness and metastasis [PMID: 11992541]. Basigin has also been repeatedly implicated in the proper function of the blood brain barrier [PMID: 2357963, PMID: 1383894]. In addition, the protein is essential for fertility in both males and females [PMID: 9559645]. In males, it is required for the completion of spermatogenesis, while in females, it is needed for maintaining normal reproductive functions.

Basigins are highly glycosylated membrane proteins, the degree of glycosylation varying with tissue type. The extracellular region of basigin contains two randomly arranged Ig domains: an Ig-like C2-type domain and an Ig-like V-domain [PMID: 2361961].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0016020 membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER