Homologous Superfamily

Protein-L-isoaspartyl O-methyltransferase, C-terminal (IPR009107)

Short name: PIM_MeTrfase_C


Proteins can accumulate much damage as they age, such as the formation of isoaspartyl residues. Protein-L-isoaspartyl O-methyltransferase (PIMT) (IPR000682) is a nearly ubiquitous enzyme that catalyses the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues, thereby playing a role in the repair or degradation of damaged proteins. The crystal structure of PIMT from the bacteria Thermotoga maritima has been determined and reveals an alpha/beta protein with three functional subdomains. The C-terminal subdomain is unique to the PIMT of T. maritime, with no similar sequences being found in PIMTs from other species [PMID: 11080641]. These sequences form an alpha/beta subdomain in three layers, beta/alpha/beta, with a buried helix.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.