Beta-lactamase-inhibitor protein BLIP (IPR009099)

Short name: Beta-lactamas_inhib

Overlapping homologous superfamilies

Family relationships



The beta-lactamase-inhibitor protein (BLIP) is produced by Streptomyces species. BLIP acts as a potent inhibitor of beta-lactamases such as TEM-1, which is the most widespread resistance enzyme to penicillin antibiotics. BLIP binds competitively to TEM-1 and makes direct contacts with TEM-1 active site residues. BLIP is able to inhibit a variety of class A beta-lactamases, possibly through flexibility of its two domains. The two tandemly repeated domains of BLIP have an alpha(2)-beta(4) structure, the beta-hairpin loop from domain 1 inserting into the active site of beta-lactamase [PMID: 8605632]. BLIP shows no sequence similarity with BLIP-II, even though both bind to and inhibit TEM-1 [PMID: 11573088].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.