Homologous Superfamily

Cyclic phosphodiesterase (IPR009097)

Short name: cNuc_Pdiesterase

Overlapping entries


This entry represents a beta-barrel domain consisting of a duplication of a beta/alpha/beta/alpha/beta motif, which is found in plant cyclic phosphodiesterases (CPDases) [PMID: 11694509], as well as catalytic domains from mammalian 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase) [PMID: 17480208], and bacterial and archaeal LigT-like 2',3'-cyclic phosphodiesterases (originally identified as 2'-5' RNA ligases) [PMID: 25239919]. This beta-barrel domain is similar in structure to the beta-barrel found in prokaryotic DNA topoisomerases I and III.

The catalytic domain of CNPase from animals catalyzes the hydrolysis of nucleoside 2',3'-cyclic monophosphates to nucleoside 2'-monophosphates [PMID: 26563764]. The archaeobacterial LigT-like enzymes hydrolyze 2',3'-cyclic phosphate in (oligo)nucleotides and join the produced 2'-phosphate to a 5'-hydroxyl group of another (oligo)nucleotide to form atypical 2',5'-linkages. Such activity has not been reported for CNPase [PMID: 23831225].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.