Homologous Superfamily

Vpu protein cytoplasmic domain superfamily (IPR009032)

Short name: Vpu_cyt_dom_sf

Overlapping entries


The human immunodeficiency virus type 1 Vpu transmembrane protein is required for the induction of degradation human CD4 receptor degradation in the endoplasmic reticulum, and for the enhancement of virus particle release from the plasma membrane of infected cells. The cytoplasmic domain of Vpu directly interacts with the CD4 receptor, targeting it for proteasome degradation [PMID: 7853484]. The cytoplasmic domain encompasses the C-terminal half of the 81-residue protein, and is comprised of a few helical turns without an apparent hydrophobic core [PMID: 9182993].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0042609 CD4 receptor binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.