Homologous Superfamily

L-fucose isomerase, N-terminal/central domain superfamily (IPR009015)

Short name: Fucose_isomerase_N/cen_sf

Description

L-fucose isomerase (EC:5.3.1.25) converts the aldose L-fucose into the corresponding ketose L-fuculose during the first step in fucose metabolism using Mn2+ as a cofactor. The enzyme is a hexamer, forming the largest structurally known ketol isomerase, and has no sequence or structural similarity with other ketol isomerases. L-fucose isomerase is composed of three domains, the N-terminal, central and C-terminal domains. The N-terminal and central domains have a similar topology, consisting of three layers (alpha/beta/alpha) each. The N-terminal domain has a parallel beta-sheet of five strands in the order S2, S1, S3, S4, S5, while the central domain has a parallel beta-sheet of four strands in the order S2, S1, S3, S4 [PMID: 9367760].

GO terms

Biological Process

GO:0005996 monosaccharide metabolic process

Molecular Function

GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses

Cellular Component

GO:0005737 cytoplasm

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
SUPERFAMILY