Agglutinin domain (IPR008998)

Short name: Agglutinin

Overlapping homologous superfamilies

Domain relationships



Agglutinins are sugar-specific lectins that can agglutinate erythrocytes and other cell types. Lectins occur widely in plants, as well as some microorganisms and animal [PMID: 15229195]. Agglutinin from Amaranthus caudatus (amaranthin) is a lectin from the ancient South American crop, amaranth grain. Although its biological function is unknown, it can agglutinate A, B and O red blood cells, and has a carbohydrate-binding site that is specific for the methyl-glycoside of the T-antigen found linked to serine or threonine residues of cell surface glycoproteins [PMID: 2271665]. The protein is comprised of a homodimer, with each homodimer consisting of two beta-trefoil domains [PMID: 2777780]. Lectin B chains from ricin and related toxins also contain beta-trefoil domain, however they are not related to agglutinin, showing little sequence similarity [PMID: 9334739].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.