
Overview

Pathways & interactions

Crossreferences
Cytokine IL1/FGF (IPR008996)
Short name: IL1/FGF
Overlapping entries
 Interleukin1 family (IPR000975)
 Fibroblast growth factor family (IPR002209)
 Interleukin1 alpha (IPR003295)
 Interleukin1 beta (IPR003296)
 Interleukin18 (IPR015529)
 Interleukin36 alpha (IPR027163)
 Interleukin1 family member 10 (IPR027164)
 Interleukin36 receptor antagonist (IPR027171)
 Interleukin36 beta (IPR027172)
 Fibroblast growth factor 1 (IPR028210)
 Fibroblast growth factor 2 (IPR028223)
 Fibroblast growth factor 3 (IPR028232)
 Fibroblast growth factor 4 (IPR028239)
 Fibroblast growth factor 5 (IPR028240)
 Fibroblast growth factor 6 (IPR028242)
 Fibroblast growth factor 7 (IPR028247)
 Fibroblast growth factor 9 (IPR028251)
 Fibroblast growth factor 10 (IPR028252)
 Fibroblast growth factor 11 (IPR028253)
 Fibroblast growth factor 12 (IPR028254)
 Fibroblast growth factor 13 (IPR028279)
 Fibroblast growth factor 14 (IPR028284)
 Fibroblast growth factor 16 (IPR028285)
 Fibroblast growth factor 17 (IPR028287)
 Fibroblast growth factor 18 (IPR028289)
 Fibroblast growth factor 20 (IPR028291)
 Fibroblast growth factor 21 (IPR028292)
 Fibroblast growth factor 22 (IPR028296)
 Fibroblast growth factor 15/19 (IPR028303)
 Fibroblast growth factor 23 (IPR028304)
 Fibroblast growth factor 15/19/21 (IPR035444)
Description
This entry includes IL1 and FGF.
The interleukin1 (IL1) and fibroblast growth factor (FGF, also known as heparinbinding growth factor) families share low sequence similarity (about 25% [PMID: 1849658]) but have very similar structures. They belong to a superfamily that also contains the Kunitztype soybean trypsin inhibitors (STIs), all of which have very similar structures. However, IL1 and FGF share no sequence similarity with the STI family.
The crystal structures of interleukin1 beta and HGF1 have been solved, showing both families to have the same 12stranded betasheet structure [PMID: 1738162]; the betasheets are arranged in 3 similar lobes around a central axis, 6 strands forming an antiparallel betabarrel [PMID: 1707542, PMID: 4071057]. The betasheets are generally well preserved and the crystal structures superimpose in these areas. The intervening loops are less well conserved  the loop between betastrands 6 and 7 is slightly longer in interleukin1 beta.
Contributing signatures
 SSF50353 (SSF50353)