Adenovirus pIV-related, attachment domain (IPR008982)

Short name: Adenovirus_pIV-rel_att

Domain relationships


The viral attachment protein domain forms part of the fibre proteins in adenoviruses [PMID: 10567268], and the sigma 1 protein in reoviruses [PMID: 11782420]. Both proteins are trimers that contain fibrous tails and globular heads (reovirus), or knobs (adenovirus), which are structurally very similar. Both domain cores consist of eight anti-parallel beta-sheets, forming either a beta sandwich (fibre knob), or a beta-barrel (sigma 1 head), with a long loop containing an alpha helix. The remaining loops tend to be longer in the fibre knob. Functionally both the fibre knob and the sigma 1 head are involved in binding selectively to cell surface receptors. The reoviruses bind JAM (junction adhesion molecule), while the adenoviruses use the CAR (Coxsackievirus and adenovirus) receptor, with the exception of subgroup B adenoviruses [PMID: 11437664].

GO terms

Biological Process

GO:0007155 cell adhesion
GO:0019058 viral life cycle
GO:0019062 virion attachment to host cell

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.