Vps72/YL1 family (IPR008895)

Short name: Vps72/YL1

Overlapping homologous superfamilies


Family relationships



This entry include a group of proteins involved in chromatin remodelling, including Vps72 (vacuolar protein sorting-associated protein 72) from budding yeasts. Vps72 is a Htz1-binding component of the SWR1 complex, which is required for the incorporation of the histone variant H2AZ into chromatin [PMID: 23580526]. It is also required for vacuolar protein sorting in budding yeasts [PMID: 23580526].

The Vps72 homologue from flies, YL-1, is part of the Tip60 chromatin-remodelling complex which is involved in DNA repair [PMID: 15528408].

GO terms

Biological Process

GO:0006338 chromatin remodeling
GO:0043486 histone exchange
GO:0006355 regulation of transcription, DNA-templated

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.