Thiazole synthase (IPR008867)

Short name: ThiG

Overlapping homologous superfamilies

Family relationships



Thiazole synthase (ThiG) is the tetrameric enzyme involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes the formation of thiazole from 1-deoxy-D-xylulose 5-phosphate (DXP) and dehydroglycine, with the help of the sulfur carrier protein ThiS that carries the sulfur needed for thiazole assembly on its carboxy terminus (ThiS-COSH) [PMID: 15012138, PMID: 15489164].

GO terms

Biological Process

GO:0009228 thiamine biosynthetic process

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.