TPMT family (IPR008854)

Short name: TPMT

Overlapping homologous superfamilies

Family relationships


This family consists of thiopurine S-methyltransferase (EC:, thiol S-methyltransferase (EC: and thiocyanate methyltransferase (EC:2.1.1.n4).

Thiopurine S-methyltransferase is a cytosolic enzyme that catalyses S-methylation of aromatic and heterocyclic sulphydryl compounds, including anticancer and immunosuppressive thiopurines [PMID: 9780226]. Thiopurine is commonly used to suppress the immune system in the case of autoimmune disease, inflammatory bowel disease and to prevent transplanted organ rejection [PMID: 16207256]. Thiopurine drugs can be toxic to cells but their effect can be mediated by the incorporation of thioguanine nucleotides into DNA [PMID: 15570193].

Thiocyanate methyltransferase and thiol S-methyltransferase are involved in glucosinolate metabolism and defense against phytopathogens. Thiocyanate methyltransferase is highly reactive to thiocyanate (NCS-) derived from myrosinase-mediated hydrolysis of glucosinolates upon tissue damage [PMID: 19419967].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0008757 S-adenosylmethionine-dependent methyltransferase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles