L6 membrane (IPR008661)

Short name: L6_membrane

Overlapping homologous superfamilies


Family relationships



This family consists of several eukaryotic L6 membrane proteins. L6, IL-TMP, and TM4SF5 are cell surface proteins predicted to have four transmembrane domains. Previous sequence analysis led to their assignment as members of the tetraspanin superfamily it has now been found that that they are not significantly related to genuine tetraspanins, but instead constitute their own L6 family [PMID: 10975581]. Several members of this family have been implicated in Homo sapiens cancer [PMID: 1565644, PMID: 9479038].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.