Herpesvirus UL45-like (IPR008646)

Short name: Herpes_UL45-like

Overlapping homologous superfamilies


Family relationships


This family consists several UL45 proteins and homologues found in the herpes simplex virus family. The herpes simplex virus UL45 gene encodes an 18kDa virion envelope protein whose function remains unknown. It has been suggested that the 18kDa UL45 gene product is required for efficient growth in the central nervous system at low doses and may play an important role under the conditions of a naturally acquired infection [PMID: 11958453]. The Equine herpesvirus 1 UL45 protein represents a type II membrane glycoprotein which has found to be non-essential for EHV-1 growth in vitro but deletion reduces the viruses' replication efficiency [PMID: 11145911].

Studies have shown that UL45 has a C-type lectin-like fold, suggesting that it might have a carbohydrate-binding function [PMID: 18256535, PMID: 20080138].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.