Filamentous haemagglutinin repeat (IPR008619)

Short name: Filamentous_hemagglutn_rpt


This highly divergent repeat occurs in number of filamentous haemagglutinin (FHA) proteins implicated in cell aggregation [PMID: 2539596]. Filamentous haemagglutinin from Bordetella pertussis, the infectious agent in childhood whooping cough, expresses filamentous haemagglutinin as a surface-exposed and secreted protein that acts as a major virulence attachment factor, functioning as both a primary adhesin and an immunomodulator to bind the bacterial to cells of the respiratory epithelium [PMID: 16339899]. The FHA molecule has a globular head that consists of two domains: a shaft and a flexible tail. Its sequence contains two regions of tandem 19-residue repeats, where the repeat motif consists of short beta-helical strands separated by beta-turns [PMID: 7519681].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.