Pathways & interactions
Microtubule-associated protein 7 family (IPR008604)
Short name: MAP7_fam
Overlapping homologous superfamilies
- Microtubule-associated protein 7 family (IPR008604)
- Microtubule-associated protein 7 (IPR030707)
MAP7 (also known as E-MAP-115 or Ensconsin) is a microtubule-stabilising protein that may play an important role in microtubule reorganisation during polarisation and differentiation of epithelial cells [PMID: 11719555]. It may play a role in the formation of intercellular contacts [PMID: 11719555, PMID: 9989799].
The MAP7 family has three other members: MAP7 domain containing proteins 1 (MAP7D1), 2 (MAP7D2) and 3 (MAP7D3) [PMID: 24927501]. MAP7D3 has been identified as a critical regulator of microtubule stability, probably through its binding to tubulin and microtubules, as well as its regulation of histone deacetylase 6 activity [PMID: 22142902, PMID: 24614595].
- PF05672 (MAP7)