GINS complex subunit Sld5 (IPR008591)

Short name: GINS_Sld5

Overlapping homologous superfamilies

Family relationships



GINS is a key component of eukaryotic replicative forks. It is part of the CMG (Cdc45-MCM-GINS) complex, the eukaryotic replicative helicase that unwinds double-stranded DNA at replication forks [PMID: 23412083]. Beside its role as a key component of the CMG complex, GINS mediates a interactions with many replication factors [PMID: 22918584, PMID: 20070258].

GINS is composed of four subunits: Sld5, Psf1, Psf2, and Psf3 [PMID: 23412083]. The four subunits are structurally related and are likely to derive from a single protein. They share a common fold made up of an alpha-helical A domain and a beta rich B domain. Sld5 and Psf1 possess the A domain at the N terminus and the B domain at the C terminus, whereas these two domains are swapped in Psf2 and Psf3 [PMID: 28071757]. All subunits are essential for DNA replication.

This family of proteins represents the Sld5 subunit.

GO terms

Biological Process

GO:0006261 DNA-dependent DNA replication

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.