Calcium load-activated calcium channel (IPR008559)

Short name: TMCO1

Overlapping homologous superfamilies


Family relationships


Maintaining homeostasis of Ca2+ stores in the endoplasmic reticulum (ER) is crucial for proper Ca2+ signaling. Calcium load-activated calcium channel, also known as transmembrane and coiled-coil domains 1 (TMCO1), is an ER transmembrane protein that prevents Ca2+ ER stores from overfilling. In response to ER overloading, TMCO1 undergoes reversible homotetramerization and forms a Ca(2+)-selective ion channel [PMID: 27212239].

GO terms

Biological Process

GO:0032469 endoplasmic reticulum calcium ion homeostasis

Molecular Function

GO:0005262 calcium channel activity

Cellular Component

GO:0030176 integral component of endoplasmic reticulum membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.