Coiled-coil domain-containing protein 22 (IPR008530)

Short name: CCDC22

Family relationships



Human coiled-coil domain-containing protein 22 (CCDC22) is involved in regulation of NF-kappa-B signalling; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex [PMID: 23563313]. It is part of the OMMD/CCDC22/CCDC93 (CCC) complex, which interacts with the multisubunit WASH complex required for endosomal deposition of F-actin and cargo trafficking in conjunction with the retromer [PMID: 25355947].

This entry also includes CCDC22 homologues from animals and plants.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.