Na,K-Atpase Interacting protein (IPR008516)

Short name: Na/K-Atpase_Interacting

Family relationships



NKAIN (Na,K-Atpase INteracting) proteins are a family of evolutionary conserved transmembrane proteins that localise to neurons, that are critical for neuronal function, and that interact with the beta subunits, beta1 in vertebrates and beta in Drosophila, of Na,K-ATPase. NKAINs have highly conserved trans-membrane domains but otherwise no other characterised domains. NKAINs may function as subunits of pore or channel structures in neurons or they may affect the function of other membrane proteins. They are likely to function within the membrane bilayer [PMID: 17606467].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.