SRP-independent targeting protein 2/TMEM208 (IPR008506)

Short name: SND2/TMEM208

Family relationships



This family includes SRP-independent targeting protein 2 (SND2) from yeast and transmembrane protein 208 (TMEM208) from mammals. Both are localized to the endoplasmic reticulum (ER) [PMID: 27905431, PMID: 23691174]. SND2 works together with SND1 and SND3 in an alternative targeting route to the ER [PMID: 27905431]. TMEM208 regulates both ER stress and autophagy [PMID: 23691174].

SND2 was previously known as Env10 in Saccharomyces cerevisiae, and its homologue as Mug69 in Schizosaccharomyces pombe. They were identified as proteins involved in vacuolar processing and morphology [PMID: 21912603] and meiosis [PMID: 16303567], respectively.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.