Family

THO complex subunit 7/Mft1 (IPR008501)

Short name: THOC7/Mft1

Family relationships

None.

Description

The THO complex (THOC) is involved in transcription elongation and mRNA export from the nucleus [PMID: 15133499]. This entry represents the subunit THOC7, which is found in higher eukaryotes, and the non-homologous subunit Mft1 found in yeast.

Mft1 is a component the THO subcomplex of the TREX complex, which operates in coupling transcription elongation to mRNA export [PMID: 12093753]. The THO complex is recruited to transcribed genes and moves along the gene with the elongating polymerase during transcription [PMID: 12871933]. THO is important for stabilising nascent RNA in the RNA polymerase II elongation complex by preventing formation of DNA:RNA hybrids behind the elongating polymerase [PMID: 14527416]. It functions in cotranscriptional formation of an export-competent messenger ribonucleoprotein particle (mRNP) by facilitating the loading of ATP-dependent RNA helicase Sub2 and the mRNA export factor Yra1 along the nascent mRNA [PMID: 15192704].

In mammals, the THO complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. It binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export [PMID: 15998806, PMID: 17190602].

GO terms

Biological Process

GO:0006397 mRNA processing

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0000445 THO complex part of transcription export complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam