Family

CDK5 regulatory subunit-associated protein 3 (IPR008491)

Short name: CDK5RAP3

Family relationships

None.

Description

CDK5RAP3 (also known as C53 or LZAP) serves as a probable tumour suppressor initially identified as a CDK5R1 interactor controlling cell proliferation [PMID: 12054757, PMID: 12737517]. It negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation [PMID: 17785205, PMID: 20228063]. It also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint [PMID: 15790566, PMID: 19223857]. It has been shown to bind Wip1 and stimulates its phosphatase activity [PMID: 28027003].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
PANTHER