Domain

Collagen binding domain (IPR008456)

Short name: Collagen-bd_dom

Domain relationships

None.

Description

The domain fold is a jelly-roll, composed of two antiparallel beta-sheets and two short alpha-helices [PMID: 9334749]. A groove on beta-sheet I exhibited the best surface complementarity to the collagen. This site partially overlaps with the peptide sequence previously shown to be critical for collagen binding. Recombinant proteins containing single amino acid mutations designed to disrupt the surface of the putative binding site exhibited significantly lower affinities for collagen.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0005518 collagen binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam