Domain

Collagen-binding surface protein Cna-like, B-type domain (IPR008454)

Short name: Collagen-bd_Cna-like_B-typ_dom

Domain relationships

None.

Description

This entry represents a repeated B region domain found in the collagen-binding surface protein Cna in Staphylococcus aureus, as well as other related domains. The B region domain of Cna has a prealbumin-like beta-sandwich fold of seven strands in two sheets with a Greek key topology [PMID: 10673425]. However, this domain does not mediate collagen binding, the IPR008456 region carries out that function; instead it appears to form a stalk that presents the ligand binding domain away from the bacterial cell surface. Cna is a collagen-binding MSCRAMM (Microbial Surface Component Recognizing Adhesive Matrix Molecules), and is necessary and sufficient for S. aureus cells to adhere to cartilage.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam