SPHK1-interactor/A-kinase anchor 110kDa (IPR008382)

Short name: SPHK1-interactor_AKAP_110

Overlapping homologous superfamilies


Family relationships


This family consists of several mammalian protein kinase A anchoring protein 3 (PRKA3) or A-kinase anchor protein 110 kDa (AKAP 110) sequences. Agents that increase intracellular cAMP are potent stimulators of sperm motility. Anchoring inhibitor peptides, designed to disrupt the interaction of the cAMP-dependent protein kinase A (PKA) with A kinase-anchoring proteins (AKAPs), are potent inhibitors of sperm motility. PKA anchoring is a key biochemical mechanism controlling motility. AKAP110 shares compartments with both RI and RII isoforms of PKA and may function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction [PMID: 10319321].

SPHK1-interactor and AKAP domain-containing proteins are proteins that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II). May act as a converging factor linking cAMP and sphingosine signaling pathways. Plays a regulatory role in the modulation of SPHK1 [PMID: 12080051].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.