Band 4.1, C-terminal (IPR008379)

Short name: Band_4.1_C

Overlapping homologous superfamilies


Domain relationships



There is a unique sequence domain at the C terminus of all known 4.1 proteins, known as the C-terminal domain (CTD). Mammalian CTDs are associated with a growing number of protein-protein interactions, although such activities have yet to be associated with invertebrate CTDs. Mammalian CTDs are generally defined by sequence alignment as encoded by exons 18-21. Comparison of known vertebrate 4.1 proteins with invertebrate 4.1 proteins indicates that mammalian 4.1 exon 19 represents a vertebrate adaptation that extends the sequence of the CTD with a Ser/Thr-rich sequence. The CTD was first described as a 22/24kDa domain by chymotryptic digestion of erythrocyte 4.1 (4.1R). CTD is thought to represent an independent folding structure which has gained function since the divergence of vertebrates from invertebrates [PMID: 11432737].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0003779 actin binding
GO:0005198 structural molecule activity

Cellular Component

GO:0005856 cytoskeleton

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.