Synembryn (IPR008376)

Short name: Synembryn

Overlapping homologous superfamilies


Domain relationships



Synembryns are proteins that positively regulate synaptic transmission. They are actively required to maintain proper activity of the Go to Gq G-protein signalling network, which regulates neurotransmitter secretion in Caenorhabditis elegans by controlling the production and consumption of diacylglycerol [PMID: 10985349]. In addition to its role in the adult nervous system, synembryn is required to regulate a subset of centrosome movements in the early C. elegans embryo [PMID: 11102364].

The protein appears to be concentrated in the cytoplasm of neurons. However, unlike other protein components of the Go-Gq signalling network, synembryn appears to be more concentrated in the cell soma than in axonal processes throughout the nervous system [PMID: 10985349]. C. elegans synembryn reduction of function mutants exhibit partial embryonic lethality [PMID: 11102364].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.