Lantibiotic leader peptide-processing serine protease (IPR008357)

Short name: Lanit_process

Family relationships


Lantibiotic genes reside on the bacterial chromosome, where they cluster with genes that adapt and secrete them to the extracellular space. Many of these so-called 'pathogenicity islands' have been characterised, including the epidermin (epi) cluster in Staphylococcus epidermis, and the nisin (nis) cluster in Lactococcus lactis [PMID: 11133423]. The gene encoding the lantibiotic is flanked by 3 regulatory genes: 2 that are usually involved in a 2-component regulatory system, and another that cleaves the signal peptide from the precursor to produce the mature lantibiotic.

This protein (usually designated with a "P" suffix - nisP, mutP, etc.) is highly conserved amongst pathogenic species, and is essential for virulence and survival of the bacterium against competitors in the host [PMID: 11133423]. A novel pathogenicity island in resistant Enterococcus faecalis has been sequenced. In addition to the lantibiotic Cyl gene cluster, this revealed a novel set of virulence factors involved in vancomycin resistance and pathogenicity [PMID: 12066186].

Lantiobiotic (lanthionine-containing antibiotics) specific proteases are serine proteases in the subtilisin family (family S8). The proteases that cleave the N-terminal leader peptides from lantiobiotics include: epiP, nsuP, mutP, and nisP. EpiP (MEROPS identifier S08.060), from Staphylococcus, is thought to cleave matured epidermin [PMID: 8550430]. NsuP, a dehydratase from Streptococcus and NisP (MEROPS identifier S08.059), a membrane-anchored protease from Lactococcus, cleaves nisin [PMID: 8478324]. MutP (MEROPS identifier S08.065) is highly similar to epiP and nisP and is thought to process the prepeptide mutacin III of S. mutans [PMID: 10473390].

GO terms

Biological Process

GO:0006508 proteolysis

Molecular Function

GO:0004252 serine-type endopeptidase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
  • cd07482 (Peptidases_S8_Lantibiotic_spec)