Flavoprotein pyridine nucleotide cytochrome reductase-like, FAD-binding domain (IPR008333)

Short name: Cbr1-like_FAD-bd_dom

Overlapping homologous superfamilies

Domain relationships


These sequences represent the FAD-binding domain found in NADH:cytochrome b5 reductases and nitrate reductases.

To date, the 3D-structures of the flavoprotein domain of Zea mays (Maize) nitrate reductase [PMID: 7812715] and of pig NADH:cytochrome b5 reductase [PMID: 7893687] have been solved. The overall fold is similar to that of ferredoxin:NADP+ reductase [PMID: 8027025]: the FAD-binding domain (N-terminal) has the topology of an anti-parallel beta-barrel, while the NAD(P)-binding domain (C-terminal) has the topology of a classical pyridine dinucleotide-binding fold (i.e. a central parallel beta-sheet flanked by 2 helices on each side).

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.