Poly [ADP-ribose] polymerase (IPR008288)

Short name: PARP

Overlapping homologous superfamilies


Family relationships



Poly(ADP-ribose) synthase and poly(ADP-ribose) polymerase (PARP, also known as ADPRT) catalyse the DNA-dependent covalent attachment of ADP-ribose to various nuclear proteins [PMID: 3118181]. They are used by the eukaryotic cell to cope with numerous environmental and endogenous genotoxic agents that cause DNA strand breaks. PARP plays a role in many cellular processes, including DNA repair, recombination, cell proliferation and death, as well as genomic stability [PMID: 11781113]. The DNA-binding region of the protein contains a pair of zinc finger domains, which have been shown to bind DNA in a zinc-dependent manner [PMID: 6088227]. PARP also contains a BRCT domain involved in cell cycle checkpoint functions responsive to DNA damage [PMID: 9034168], a catalyic domain and a regulatory domain.

GO terms

Biological Process

GO:0006471 protein ADP-ribosylation

Molecular Function

GO:0003677 DNA binding
GO:0051287 NAD binding
GO:0003950 NAD+ ADP-ribosyltransferase activity
GO:0008270 zinc ion binding

Cellular Component

GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.