PEP-utilising enzyme, mobile domain (IPR008279)

Short name: PEP-util_enz_mobile_dom

Overlapping homologous superfamilies

Domain relationships


A number of enzymes that catalyze the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) via a phospho-histidine intermediate have been shown to be structurally related [PMID: 7686067, PMID: 8973315, PMID: 2176881, PMID: 1557039]. All these enzymes share the same catalytic mechanism: they bind PEP and transfer the phosphoryl group from it to a histidine residue. This domain is a "swivelling" beta/beta/alpha domain which is thought to be mobile in all proteins known to contain it [PMID: 12083528]. It is often found associated with the pyruvate phosphate dikinase, PEP/pyruvate-binding domain (IPR002192) at its N terminus.

GO terms

Biological Process

GO:0016310 phosphorylation

Molecular Function

GO:0016772 transferase activity, transferring phosphorus-containing groups

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.